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Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse
Author(s) -
Graham S. D.,
Poulton S. H.,
Woodard B. H.,
Lyles K. W.,
Paulson D. F.,
Linder J.
Publication year - 1985
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990070405
Subject(s) - hypophosphatemia , adenocarcinoma , prostate , androgen , acid phosphatase , prostatic acid phosphatase , prostatic adenocarcinoma , endocrinology , cancer research , medicine , cell culture , estrogen , nude mouse , biology , hormone , cancer , biochemistry , enzyme , genetics
There are few established human prostatic adenocarcinoma cell lines in existence. Most established lines are nonfunctional and hormonally insensitive. A human prostate adenocarcinoma (9479) has been serially transplanted for more than 4 years in athymic nude mice. The tumor is estrogen and androgen insensitive, is transplantable between mice with a high rate of success. The tumor does not produce enzymatically measurable acid phosphatase, but does produce immunologically identifiable acid phosphatase. Not only has the tumor retained its original morphology, it also appears to produce a factor producing hypophosphatemia. Current studies in regards to the endocrinological aspects of this tumor are in progress. We propose that acid phosphatase is produced, but in an altered form.