Premium
Relationships between estrogen intake, serum testosterone, and tumor androgen, estrogen, and progesterone receptor levels in diethylstilbestrol‐treated rats bearing the R3327 prostatic adenocarcinoma
Author(s) -
Mobbs B. G.,
Johnson I. E.
Publication year - 1985
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990070307
Subject(s) - diethylstilbestrol , endocrinology , medicine , testosterone (patch) , estrogen , androgen , androgen receptor , estrogen receptor , prostate cancer , prostate , hormone , cancer , breast cancer
The relationships between intake of diethylstilbestrol (DES), serum testosterone, prostate weight, and the tumor steroid receptor content were investigated in male Copenhagen x Fischer F 1 hybrid rats bearing the R3327H tumor after treatment for 20 days with graded doses of diethylstilbestrol diphosphate. It was found that the wet weights of the ventral and dorsolateral prostate glands were positively linearly related to the log of the serum testosterone level (P < 0.001). The cellular distribution of androgen receptor (AR) in the tumors of the treated animals was consistent with the androgen deprivation brought about by the treatment, and nuclear AR concentrations were also linearly related to the log of the serum testosterone levels (P < 0.001). Although nuclear estrogen receptor could not be consistently demonstrated in these tumors, cytosol progesterone levels were linearly related to the amount of DES ingested during the treatment period (P < 0.001).