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Effect of estrogen and androgen administration on α‐difluoro‐methylornithine‐enhanced putrescine uptake by the rat prostate
Author(s) -
Kadmon D.,
Mahle C.,
Heston W. D. W.,
Hahn D. A.
Publication year - 1985
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990060403
Subject(s) - putrescine , prostate , androgen , prostate carcinoma , endocrinology , polyamine , castration , prostate cancer , medicine , stimulation , estrogen , spermidine , chemistry , hormone , cancer , biochemistry , enzyme
Radiolabeled putrescine is a potential imaging agent for carcinoma of the prostate. The intrinsically high uptake of putrescine into the rat prostate and prostatic carcinoma can be further stimulated by pretreatment of the animals with α‐difluoromethylornithine (DFMO) uptake, a polyamine synthesis inhibitor. Pharmacological castration of the animals followed by androgen stimulation and DFMO pretreatment achieved a 30:1 prostate/muscle ratio of 14 C‐putrescine uptake in elderly rats.