Premium
Promotional effects of testosterone and dietary fat on prostate carcinogenesis in genetically susceptible rats
Author(s) -
Pollard Morris,
Luckert Phyllis H.
Publication year - 1985
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990060102
Subject(s) - prostate cancer , prostate , testosterone (patch) , medicine , corn oil , prostatitis , incidence (geometry) , endocrinology , cancer , tramp , physiology , physics , optics
Germfree (GF) Lobund strain Wistar (LW) rats, fed vegetable diet L‐485, have developed prostate adenocarcinomas spontaneously (10% incidence) at average age 34 months. Conventional LW rats, implanted with testosterone at age 4 months, developed a higher incidence of prostate cancer after an average interval of 14 months: 24% had developed gross tumors, and 40% when it included microscopic tumors. Preliminary results indicate that testosterone‐treated LW rats that were fed the same diet, which was supplemented with corn oil up to 20% fat, developed prostate cancer after intervals of 6–12 months. Aged GF Sprague‐Dawley (SD) rats have not developed prostate cancer spontaneously. Conventional SD rats fed diet L‐485 and treated with testosterone developed only prostatitis. Experimental designs should consider genetic susceptibility as a basic prerequisite for studies on experimental prostate cancer.