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Treatment of prostatitis in the rat
Author(s) -
Lundgren Rolf,
Holmquist Bo,
Hesselvik Margareta,
Müntzing Jonas
Publication year - 1984
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990050305
Subject(s) - prostatitis , medicine , methylprednisolone , testosterone (patch) , prostate , rat model , endocrinology , urology , cancer
A spontaneous, nonacute, age‐dependent prostatitis was found in a high incidence in the lateral prostatic lobes of Lewis rats. Such rats were treated with methylprednisolone, indometacin, testosterone, hexyloxyphenylproprionate, polyestradiol phosphate, various antibiotics, or were caged together with female rats. The effect of the different treatment modalities was evaluated microscopically by blind observation of the degree of inflammatory reaction in the lateral prostate. Methylprednisolone and the testosterone ester caused a reduction of the inflammatory reactions and so did caging with female rats. The similarity of the rat prostatitis to the human condition may suggest the possibility of using corticosteroids or androgens for the treatment of patients with nonacute prostatitis.