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Acid phosphatase‐producing androgen‐independent subline of rat prostatic adenocarcinoma (dunning r3327 tumor) in cell culture
Author(s) -
Igarashi Tatsuo,
Isaka Shigeo,
Miyauchi Taisei,
Hayata Isamu,
Shimazaki Jun
Publication year - 1984
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990050111
Subject(s) - prostatic adenocarcinoma , adenocarcinoma , androgen , acid phosphatase , cell culture , biology , pathology , prostatic acid phosphatase , immunohistochemistry , prostate , cancer research , endocrinology , medicine , cancer , enzyme , hormone , biochemistry , genetics
Establishment of a cell line derived from the androgen‐independent subline of rat prostatic adenocarcinoma (Dunning R3327 tumor) is reported. Cells of this line produced acid phosphatase. When the cultured cells were transplanted to Copenhagen rats, solid tumors were formed. Histologically, the tumor consisted of spindle‐shaped, large and bizarre polygonal cells; this feature was almost identical to that of the original tumor. Chromosomes were in the triploid range with seven frequently appearing marker chromosomes.