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Distribution of quinoline carboxylic acid derivatives in the dog prostate
Author(s) -
Jensen Klaus M.E.,
Madsen Paul O.
Publication year - 1983
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990040411
Subject(s) - norfloxacin , prostate , prostatitis , distribution (mathematics) , antimicrobial , quinoline , pharmacokinetics , pharmacology , carboxylic acid , urinary system , urine , antibacterial agent , medicine , chemistry , antibiotics , biology , microbiology and biotechnology , biochemistry , organic chemistry , cancer , ciprofloxacin , mathematical analysis , mathematics
The distribution in the prostate of norfloxacin and rosoxacin, both quinoline carboxylic acid derivatives, was investigated in an experimental dog model. The concentrations in prostatic interstitial fluid (PIF) and prostatic secretion (PS) of both antimicrobials were lower than the corresponding plasma (P) concentrations, as might be expected for acidic compounds. Norfloxacin achieved significantly higher PS/P and PIF/P ratios than rosoxacin following intravenous infusion; there were no differences between the two drugs in the various tissue/plasma ratios. The concentrations of both norfloxacin and rosoxacin in PIF, PS, and urine were in the minimal inhibitory range for most gram‐negative pathogens causing bacterial prostatitis and urinary tract infections. Clinical trials may be warranted for both drugs.