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Localization of acid phosphatase activity in testosterone‐treated prostatic urethra of human fetuses
Author(s) -
KellokumpuLehtinen P.
Publication year - 1983
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990040306
Subject(s) - acid phosphatase , golgi apparatus , fetus , phosphatase , prostatic acid phosphatase , enzyme , alkaline phosphatase , biology , endocrinology , enzyme assay , epithelium , medicine , chemistry , pathology , biochemistry , cell , pregnancy , genetics
Androgens accelerated differentiation of human fetal urethral epithelial cells into secretory prostatic cells in organ culture. These epithelial cells contained supranuclear Golgi complexes in which acid phosphatase enzyme activity could be demonstrated by an electron microscopic histochemical technique. Most of the acid phosphatase activity was localized in lysosomes. Some apical precipitates could also be seen. This apical activity might be in secretory granules. Also, mesenchymal cells contained this enzyme.