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The glycosaminoglycans of normal and hyperplastic prostate
Author(s) -
De Klerk Daniel P.
Publication year - 1983
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990040107
Subject(s) - glycosaminoglycan , prostate , stroma , hyperplasia , dermatan sulfate , chondroitin , hyaluronic acid , epithelium , endocrinology , chemistry , medicine , pathology , anatomy , chondroitin sulfate , immunohistochemistry , cancer
A study has been made of the glycosaminoglycans (GAG) of the fetus, normal adult, and benign hyperplastic prostate. In the adult normal prostate dermatan sulphate (DS) is the predominant GAG. The central zone has a slightly higher chondroitin sulphate (Ch AC) content than the peripheral Lone. Fctal prostates (22–27 weeks gestation) contain no heparan sulphatc (HS). Benign prostatic hyperplasia (BPH) has an increased content of Ch AC. On separation of BPH stroma and epithelium, the epithelial fraction contains only Ch AC and DS. HS and hyaluronic acid (HA) are confined to the prostatic stroma.