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Cadmium‐induced prostate metallothionein in the rabbit
Author(s) -
Waalkes M. P.,
Donovan M. P.,
Thomas J. A.
Publication year - 1982
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990030105
Subject(s) - metallothionein , cadmium , prostate , cytosol , zinc , cadmium chloride , chemistry , prostate gland , endocrinology , medicine , biology , biochemistry , enzyme , organic chemistry , cancer
Male rabbits injected with cadmium chloride (4 mg/kg) lead to the detection of a major metal‐containing peak in the prostate cytosol. Chromatographic profiles indicate the presence of metallothionein (MT). MT is associated with zinc ion. The rabbit prostate, like that of other species, contains zinc‐associated proteins, and this protein possesses many of the characteristics of metallothionein.