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Fundamental studies on a new antitumor antibiotic peplomycin
Author(s) -
Matsuda Akira
Publication year - 1981
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990020519
Subject(s) - bleomycin , medicine , toxicity , chemotherapy , prostate , antibiotics , oncology , chemistry , cancer , biochemistry
Results of testing in mice and rats revealed that peplomycin has a stronger antitumor effect than bleomycin (BLM). Peplomycin, a BLM analogue, also has superior organ distribution characteristics and localizes in the rat prostate. Pulmonary toxicity associated with peplomycin therapy is less severe than that which accompanies BLM therapy.