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The therapeutic effect of concurrent administration of 5‐fluorouracil and allylestrenol or hexestrol in small doses on prostatic carcinoma
Author(s) -
Takeuchi Hiroyuki
Publication year - 1981
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990020518
Subject(s) - medicine , hexestrol , carcinoma , diethylstilbestrol , fluorouracil , estrogen , castration , mammary carcinoma , urology , surgery , chemotherapy , hormone
A trial to reduce the dosage of estrogen or to substitute it by other agents was done as a treatment of prostatic carcinoma. Either the combination of 5‐FU (200 mg/day) and allylestrenol (50 mg/day), or 5‐FU and hexestrol (20 mg/day) was given to 24 cases of prostatic carcinoma, 4 of whom were relapsed hormonal‐resistant cases, 14 cases were controlled by large doses of estrogen and 6 were newly treated cases. No progressions were observed following 3 months of therapy. In 5 cases, progression was observed after 6 months. Deteriorated cases increased to 6 cases after 12 months. The effective rate, according to the “vital score,” which is proposed as a parameter of the physical condition of patients with prostatic carcinoma, was calculated to be 100% at 3 months, 77% at 6 months, and 71% at 12 months.