Premium
Metioprim‐sulphadiazine distribution in the canine prostate
Author(s) -
Iversen Peter,
Nielsen Ole S.,
Vergin Hartmut,
Madsen Paul O.
Publication year - 1981
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990020402
Subject(s) - prostate , prostatitis , genitourinary system , secretion , lung , medicine , prostatic diseases , distribution (mathematics) , prostate gland , urine , pancreas , endocrinology , urology , pathology , cancer , mathematical analysis , mathematics
Constant infusion experiments with metioprim and sulphadiazine were performed in four anesthesized dogs to determine the drugs' concentrations in prostatic secretion, prostatic interstitial fluid, prostatic tissue, urine, and serum. Metioprim showed a specific affinity for the prostate gland, whereas sulphadiazine, as expected, demonstrated lower values in prostatic secretion and tissue than in serum. The prostatic secretion: serum and prostatic tissue:serum ratios using a high‐pressure liquid chromatography assay of metioprim were 7.3 and 4.0, respectively. Furthermore, metioprim showed 3.6 to 5.7 times higher concentrations in the organs of the urogenital system, liver, lung, and pancreas than in serum. We suggest that metioprim may be useful in the treatment of bacterial prostatitis, considering its spectrum of antibacterial activity and the data presented in this study.