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Immunologic aspects of the prostate
Author(s) -
Lubaroff David M.,
Reynolds Craig W.,
Canfield Larry,
McElligott David,
Feldbush Thomas
Publication year - 1981
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.2990020302
Subject(s) - medicine , immunocompetence , cancer , prostate , cryosurgery , adenocarcinoma , prostate cancer , prostatic adenocarcinoma , immune system , antigen , pathology , cancer research , immunology , surgery
Our experiments involving the use of the Dunning R3327 adenocarcinoma as an animal model of prostatic cancer as well as clinical studies on the immunocompetence of pros‐tatic cancer patients are described. Utilizing the Dunning tumor, we have demonstrated that this transplantable adenocarcinoma of the rat prostate was similar to human prostatic cancer with respect to its macroscopic and microscopic appearances, growth rate, growth differential in male and female recipients, and some of its metastatic potential. Cryosurgery was capable of destroying the primary tumor as it can in man. Both antibody and cellular immune responses could be produced against antigens associated with the tumor cells. Tumor‐bearing rats treated by cryosurgery in combination with BCG were capable of producing an antitumor imunity that protected them from rechallenge. Clinical studies of prostatic cancer patients showed a diminished in vitro immunity, but the responses of the cancer patients were not significantly different from those of patients with benign prostatic disease.