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Death due to sepsis in patients diagnosed with prostate cancer
Author(s) -
Alanee Shaheen,
Holland Bradley,
Clemons Joseph,
Dynda Danuta
Publication year - 2019
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.23735
Subject(s) - medicine , prostate cancer , prostate , sepsis , prostate disease , cancer , oncology
Background To examine the prevalence and determinants of death due to sepsis in patients diagnosed with prostate cancer (Pca). Patients and Methods We performed a retrospective analysis of 910 986 patients diagnosed with Pca between 1992 and 2010 identified from the Surveillance, Epidemiology, and End Results (SEER) database. Prevalence of death due to sepsis after diagnosis was determined. Trends in incidence‐based mortality rate (IBMR) due to sepsis were compared with those of patients diagnosed with other common cancers. Competing risk analysis was utilized to examine the determinants of the endpoint of sepsis‐specific death (SSD) in Pca patients. Results Of the Pca patients examined, 2593 died because of sepsis. Sepsis‐related IBMR in Pca patients increased by 19‐folds from 0.62/1000 000 in 1992–12.26/1000 000 in 2010. Compared with other selected cancers, patients with Pca had the highest IBMR due to sepsis post‐cancer diagnosis, and the highest annual percentage change in IBMR due to sepsis (average annual percentage change, 13.1%; 95%CI, 9.4–16.9%). Age, race, education, marital status, and definitive therapy were all significant predictors of death due to sepsis after Pca diagnosis (all P values < 0.05). Conclusion Patients diagnosed with Pca are at increased risk of dying from sepsis, and the sepsis‐related IBMR in these patients is increasing over time. There are significant disparities in the outcome of sepsis among Pca patients that require further research.