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The Association of Diabetes and Obesity With Prostate Cancer Progression: HCaP‐NC
Author(s) -
Khan Saira,
Cai Jianwen,
Nielsen Matthew E.,
Troester Melissa A.,
Mohler James L.,
Fontham Elizabeth T. H.,
Hendrix Laura H.,
Farnan Laura,
Olshan Andrew F.,
Bensen Jeannette T.
Publication year - 2017
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.23342
Subject(s) - medicine , diabetes mellitus , prostate cancer , obesity , proportional hazards model , hazard ratio , cohort , cohort study , confounding , prospective cohort study , oncology , cancer , gerontology , endocrinology , confidence interval
BACKGROUND The role of race in modifying the association among diabetes, obesity, and prostate cancer (CaP) progression is not well studied. We evaluated diabetes and obesity in association with time to CaP progression in White Americans (Whites) and Black Americans (Blacks). METHODS Our study sample consisted of 363 White and 284 Black research participants from the Health Care Access and CaP Treatment in North Carolina (HCaP‐NC) cohort. The association between self‐reported diabetes or obesity and CaP progression (mean follow‐up time approximately 5 years) was assessed using Cox proportional hazards modeling, with adjustment for potential confounders. Stratum‐specific hazard ratio (HR) estimates for Whites and Blacks were evaluated. RESULTS Self‐reported diabetes was not associated with CaP progression in the cohort as a whole (HR: 0.86, 95%CI: 0.54, 1.35), or among racially defined groups (Whites, HR: 1.03, 95%CI: 0.50, 2.13 or Blacks, HR: 0.77, 95%CI: 0.43, 1.39). Obesity was positively associated with CaP progression among Whites, in models including (HR: 1.79, 95%CI: 1.08, 2.97), and excluding (HR: 1.80, 95%CI: 1.09, 2.96) diabetes as a covariate. No association was observed between obesity and CaP progression in Blacks or the cohort as whole. CONCLUSIONS Self‐reported diabetes was not associated with CaP progression In HCaP‐NC. Obesity was associated with CaP progression only among White research participants. Prostate 77:878–887, 2017 . © 2017 Wiley Periodicals, Inc.