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Circulating Antioxidant Levels and Risk of Prostate Cancer by TMPRSS2:ERG
Author(s) -
Graff Rebecca E.,
Judson Gregory,
Ahearn Thomas U.,
Fiorentino Michelangelo,
Loda Massimo,
Giovannucci Edward L.,
Mucci Lorelei A.,
Pettersson Andreas
Publication year - 2017
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.23312
Subject(s) - tmprss2 , prostate cancer , erg , medicine , prostate , oncology , oxidative stress , cancer , odds ratio , disease , cancer research , ophthalmology , retinal , covid-19 , infectious disease (medical specialty)
BACKGROUND Few studies have considered etiological differences across molecular subtypes of prostate cancer, despite potential to improve opportunities for precision prevention of a disease for which modifiable risk factors have remained elusive. Factors that lead to DNA double‐strand breaks, such as oxidative stress, may promote the formation of the TMPRSS2:ERG gene fusion in prostate cancer. We tested the hypothesis that increasing levels of pre‐diagnostic circulating antioxidants, which may reduce oxidative stress, are associated with lower risk of developing TMPRSS2:ERG positive prostate cancer. METHODS We conducted a nested case‐control study, including 370 cases and 2,470 controls, to evaluate associations between pre‐diagnostic α‐ and β‐carotene, α‐ and γ‐tocopherol, β‐cryptoxanthin, lutein, lycopene, retinol, and selenium with the risk of prostate cancer by ERG protein expression status (a marker of TMPRSS2:ERG ). Multivariable unconditional polytomous logistic regression was used to calculate odds ratios and 95% confidence intervals. RESULTS We did not find any of the antioxidants to be significantly associated with the risk of prostate cancer according to ERG status. CONCLUSIONS The results do not support the hypothesis that circulating pre‐diagnostic antioxidant levels protect against developing TMPRSS2:ERG positive prostate cancer. Additional studies are needed to explore mechanisms for the development of TMPRSS2:ERG positive disease. Prostate 77: 647–653, 2017 . © 2017 Wiley Periodicals, Inc.