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Histopathological features of intra‐ductal carcinoma of prostatic and high grade prostatic intraepithelialneoplasia and correlation with PTEN and P63
Author(s) -
TorabiNezhad Simin,
Malekmakan Leila,
Mashayekhi Mohadese,
Daneshian Arghavan
Publication year - 2016
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.23130
Subject(s) - pten , prostatectomy , prostate cancer , prostate , medicine , immunohistochemistry , adenocarcinoma , pathology , urology , pathological , cancer , carcinoma , biology , apoptosis , biochemistry , pi3k/akt/mtor pathway
Background The main morphologic differential diagnosis of intra‐ductal carcinoma of prostate (IDC‐P) is high grade prostatic intraepithelialneoplasia (HGPIN). Since IDC‐P, unlike PIN, was strongly correlated with aggressive prostate cancer, differentiation of these is too necessary. So we evaluated immunohistopathological patterns and the prognostic factors of IDC‐P and HGPIN, in radical prostatectomy samples. Methods We evaluated 250 radical prostatectomy and detected 210 cases of prostatic adenocarcinoma without IDC‐P foci, 40 cases with adenocarcinoma concomitant IDC‐P, and 40 cases HGPIN; therefore, we evaluated immunohistopathological criteria in these groups. Data were analyzed using SPSS and P ‐value <0.05 was considered as the statistical significant level. Results PSA level was significantly higher in IDC‐P compared with non‐IDC‐P patients (15.7 ± 3.1 vs. 10.2 ± 4.3, P = 0.041). All pathological and morphologic features, also invasions factors were higher in IDC‐P compared to non‐IDC‐P groups ( P < 0.001). P63 was positive expressed in all IDC‐P and HGPIN specimen. PTEN protein was diffusely expressed in the cytoplasm of all HGPIN but in 4 (11.1%) of IDC‐P. PTEN and P63 were negative in adenocarcinoma foci. Conclusion We found that IDC‐P had a unique histoclinical feature and was strongly associated with poor prognostic factors. Diagnosis and report of IDC‐P should be considered in all prostate specimens. Also, we recommend PTEN IHC application for differentiated IDC‐P from HGPIN in biopsies. Prostate 76:394–401, 2016 . © 2015 Wiley Periodicals, Inc.