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Multidisciplinary intervention of early, lethal metastatic prostate cancer: Report from the 2015 Coffey‐Holden Prostate Cancer Academy Meeting
Author(s) -
Miyahira Andrea K.,
Lang Joshua M.,
Den Robert B.,
Garraway Isla P.,
Lotan Tamara L.,
Ross Ashley E.,
Stoyanova Tanya,
Cho Steve Y.,
Simons Jonathan W.,
Pienta Kenneth J.,
Soule Howard R.
Publication year - 2016
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.23107
Subject(s) - prostate cancer , medicine , psychological intervention , cancer , clinical trial , multidisciplinary approach , intervention (counseling) , oncology , disease , nursing , social science , sociology
Background The 2015 Coffey‐Holden Prostate Cancer Academy Meeting, themed: “Multidisciplinary Intervention of Early, Lethal Metastatic Prostate Cancer,” was held in La Jolla, California from June 25 to 28, 2015. Methods The Prostate Cancer Foundation (PCF) sponsors an annual, invitation‐only, action‐tank‐structured meeting on a critical topic concerning lethal prostate cancer. The 2015 meeting was attended by 71 basic, translational, and clinical investigators who discussed the current state of the field, major unmet needs, and ideas for addressing earlier diagnosis and treatment of men with lethal prostate cancer for the purpose of extending lives and making progress toward a cure. Results The questions addressed at the meeting included: cellular and molecular mechanisms of tumorigenesis, evaluating, and targeting the microenvironment in the primary tumor, advancing biomarkers for clinical integration, new molecular imaging technologies, clinical trials, and clinical trial design in localized high‐risk and oligometastatic settings, targeting the primary tumor in advanced disease, and instituting multi‐modal care of high risk and oligometastatic patients. Discussion This article highlights the current status, greatest unmet needs, and anticipated field changes that were discussed at the meeting toward the goal of optimizing earlier interventions to potentiate cures in high‐risk and oligometastatic prostate cancer patients. Prostate 76:125–139, 2016 . © 2015 Wiley Periodicals, Inc.