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SPINK1 expression is tightly linked to 6q15‐ and 5q21‐deleted ERG‐fusion negative prostate cancers but unrelated to PSA recurrence
Author(s) -
Grupp Katharina,
Diebel Franz,
Sirma Hüseyin,
Simon Ronald,
Breitmeyer Karin,
Steurer Stefan,
HubeMagg Claudia,
Prien Kristina,
Pham Taher,
Weigand Philipp,
Michl Uwe,
Heinzer Hans,
Kluth Martina,
Minner Sarah,
Tsourlakis Maria Christina,
Izbicki Jakob R.,
Sauter Guido,
Schlomm Thorsten,
Wilczak Waldemar
Publication year - 2013
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.22707
Subject(s) - prostate cancer , erg , prostate , pten , immunohistochemistry , pca3 , tmprss2 , cancer , medicine , tissue microarray , fusion gene , biomarker , oncology , cancer research , pathology , biology , gene , disease , genetics , apoptosis , retinal , pi3k/akt/mtor pathway , covid-19 , infectious disease (medical specialty) , ophthalmology
BACKGROUND The serine peptidase inhibitor, Kazal type 1 (SPINK1) has been suggested to define an aggressive molecular subtype of ERG‐fusion negative prostate cancer. It was the aim of this study to further study the clinical relevance of SPINK1 expression and its relationship with other key genomic alterations of prostate cancer. METHODS A tissue microarray containing more than 10,000 prostate cancers with clinical follow‐up was used for immunohistochemical SPINK1 analysis. Data on ERG status as well as PTEN, 6q, 5q, and 3p deletions were available for comparison. RESULTS SPINK1 expression was absent in benign prostate glands and detectable in 5.9% of 9,503 interpretable prostate cancers. Presence of SPINK1 expression was markedly more frequent in ERG negative (10.4%) than in ERG positive cancers (0.3%; P < 0.0001). However, SPINK1 expression was unrelated to tumor phenotype and biochemical recurrence in all cancers and in the subgroup of ERG negative cancers. Further subgroup analyses revealed, however, that—within ERG negative cancers—SPINK1 expression was significantly linked to deletions at 6q15 ( P < 0.0001) and 5q21 ( P = 0.0042). CONCLUSIONS Our results exclude SPINK1 as a relevant prognostic prostate cancer biomarker. However, the data demonstrate that SPINK1 overexpression is tightly linked to the small subsets of 6q15‐ and 5q21‐deleted ERG negative prostate cancers. These findings support the concept of molecularly defined subtypes of prostate cancers. Prostate 73: 1690–1698, 2013 . © 2013 Wiley Periodicals, Inc.