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Strain‐specific induction of experimental autoimmune prostatitis (EAP) in mice
Author(s) -
Jackson Christopher M.,
Flies Dallas B.,
Mosse Claudio A.,
Parwani Anil,
Hipkiss Edward L.,
Drake Charles G.
Publication year - 2013
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.22606
Subject(s) - prostatitis , inflammation , medicine , prostate , immunology , immunization , chronic prostatitis/chronic pelvic pain syndrome , strain (injury) , prostate diseases , immune system , cancer
BACKGROUND Prostatitis, a clinical syndrome characterized by pelvic pain and inflammation, is common in adult males. Although several induced and spontaneous murine models of prostatitis have been explored, the role of genetic background on induction has not been well‐defined. METHODS Using a standard methodology for the induction of experimental autoimmune prostatitis (EAP), we investigated both acute and chronic inflammation on several murine genetic backgrounds. RESULTS In our colony, nonobese diabetic (NOD) mice evinced spontaneous prostatitis that was not augmented by immunization with rat prostate extract (RPE). In contrast, the standard laboratory strain Balb/c developed chronic inflammation in response to RPE immunization. Development of EAP in other strains was variable. CONCLUSIONS These data suggest that Balb/c mice injected with RPE may provide a useful model for chronic prostatic inflammation. Prostate 73: 651–656, 2013. © 2012 Wiley Periodicals, Inc.