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The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland
Author(s) -
Kluźniak Wojciech,
Wokołorczyk Dominika,
Kashyap Aniruddh,
Jakubowska Anna,
Gronwald Jacek,
Huzarski Tomasz,
Byrski Tomasz,
Dębniak Tadeusz,
Gołąb Adam,
Gliniewicz Bartłomiej,
Sikorski Andrzej,
Świtała Jerzy,
Borkowski Tomasz,
Borkowski Andrzej,
Antczak Andrzej,
Wojnar Łukasz,
Przybyła Jacek,
Sosnowski Marek,
Małkiewicz Bartosz,
Zdrojowy Romuald,
SikorskaRadek Paulina,
Matych Józef,
Wilkosz Jacek,
Różański Waldemar,
Kiś Jacek,
Bar Krzysztof,
Bryniarski Piotr,
Paradysz Andrzej,
Jersak Konrad,
Niemirowicz Jerzy,
Słupski Piotr,
Jarzemski Piotr,
Skrzypczyk Michał,
Dobruch Jakub,
Domagała Paweł,
Akbari Mohammad R.,
Lubiński Jan,
Narod Steven A.,
Cybulski Cezary
Publication year - 2013
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.22594
Subject(s) - prostate cancer , medicine , odds ratio , prostate , allele , cancer , oncology , mutation , population , gynecology , genetics , biology , gene , environmental health
BACKGROUND The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20‐fold). The geographical and ethnic extent of this recurrent allele has not yet been determined. METHODS We assayed for the presence of the G84E mutation in 3,515 prostate cancer patients and 2,604 controls from Poland and estimated the odds ratio for prostate cancer associated with the allele. RESULTS The G84E mutation was detected in 3 of 2,604 (0.1%) individuals from the general population in Poland and in 20 of 3,515 (0.6%) men with prostate cancer (Odds ratio [OR] = 5.0; 95% CI: 1.5–16.7; P = 0.008). The allele was present in 4 of 416 (1.0%) men with familial prostate cancer (OR = 8.4, 95% CI: 1.9–37.7; P = 0.005). CONCLUSIONS The G84E mutation predisposes to prostate cancer in Poland, but accounts for only a small proportion of cases. We expect that the G84E founder mutation might be present in other Slavic populations. Prostate 73: 542–548, 2013. © 2013 Wiley Periodicals, Inc.