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The Monoamine Oxidase A gene promoter repeat and prostate cancer risk
Author(s) -
White Thomas A.,
Kwon Erika M.,
Fu Rong,
Lucas Jared M.,
Ostrander Elaine A.,
Stanford Janet L.,
Nelson Peter S.
Publication year - 2012
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.22515
Subject(s) - monoamine oxidase a , allele , variable number tandem repeat , prostate cancer , genotype , odds ratio , monoamine oxidase , biology , genetics , gene , oncology , medicine , cancer , enzyme , biochemistry
BACKGROUND Amine catabolism by monoamine oxidase A (MAOA) contributes to oxidative stress, which plays a role in prostate cancer (PCa) development and progression. An upstream variable‐number tandem repeat (uVNTR) in the MAOA promoter influences gene expression and activity, and may thereby affect PCa susceptibility. METHODS Caucasian (n = 2,572) men from two population‐based case‐control studies of PCa were genotyped for the MAOA ‐VNTR. Logistic regression was used to assess PCa risk in relation to genotype. RESULTS Common alleles of the MAOA ‐VNTR were not associated with the relative risk of PCa, nor did the relationship differ by clinical features of the disease. The rare 5‐copy variant (frequency: 0.5% in cases; 1.8% in controls), however, was associated with a reduced PCa risk (odds ratio, OR = 0.30, 95% CI 0.13–0.71). CONCLUSIONS A rare polymorphism of the MAOA promoter previously shown to confer low expression was associated with a reduced risk of developing PCa. This novel finding awaits confirmation in other study populations. Prostate 72:1622–1627, 2012. © 2012 Wiley Periodicals, Inc.