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Effect of 25‐hydroxyvitamin D status on serological response to influenza vaccine in prostate cancer patients
Author(s) -
Chadha Manpreet K.,
Fakih Marwan,
Muindi Josephia,
Tian Lili,
Mashtare Terry,
Johnson Candace S.,
Trump Donald
Publication year - 2010
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.21250
Subject(s) - medicine , serology , vaccination , vitamin d and neurology , antibody titer , immunology , titer , influenza vaccine , prostate cancer , cancer , gastroenterology , antibody
BACKGROUND Epidemiologic data suggest that there is an association between vitamin D deficiency and influenza infection. We conducted a prospective influenza vaccination study to determine the influence of vitamin D status on serological response to influenza vaccine in prostate cancer (CaP) patients. METHODS During the 2006–2007 influenza season, CaP patients treated at Roswell Park Cancer Institute were offered vaccination with the trivalent influenza vaccine (Fluzone®, 2006–2007) and sera collected for hemagglutination inhibition (HI) assay titers before and 3 months after vaccination. Response to vaccination was defined as ≥1:40 titer ratio or a fourfold increase in titer at 3 months, against any of the three strains. Serum 25‐hydroxyvitamin D (25‐D 3 ) levels were measured using DiaSorin 125 I radioimmunoassay kits. RESULTS Thirty‐five patients with CaP participated in the study. Median baseline 25‐D 3 level was 44.88 ng/ml (range: 9.16–71.98 ng/ml) Serological response against any of the three strains was noted in 80%. There was a significant effect of baseline 25‐D3 level when tested as a continuous variable in relation to serological response ( P = 0.0446). All patients in the upper quartile of 25‐D3 level responded by mounting a serological response ( P = 0.0344). None of the other baseline variables (age, race, chemotherapy status, or white cell count) had an effect on serological response. CONCLUSIONS In this study in CaP patients, a replete vitamin D status was associated with more frequent serological response to influenza vaccine. Prostate 77:368–372, 2011. © 2010 Wiley‐Liss, Inc.