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Meta‐analysis of genome‐wide and replication association studies on prostate cancer
Author(s) -
Liu Hong,
Wang Bo,
Han Chunsheng
Publication year - 2010
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.21235
Subject(s) - genome wide association study , single nucleotide polymorphism , prostate cancer , meta analysis , genetic association , odds ratio , biology , subgroup analysis , oncology , genetics , medicine , bioinformatics , computational biology , cancer , genotype , gene
BACKGROUND Genome‐wide and replication association studies (GWAs) have identified multiple loci at which common variants modestly influence the risk of developing prostate cancer (PCa). To enhance the power to identify loci associated with PCa, we constructed a meta‐analysis of GWAs on PCa. METHODS Articles evaluating the effects of genome‐wide SNPs on PCa were identified by searching the PubMed database. After extraction of relevant data, main and subgroup meta‐analyses were performed to assess the effects of relevant SNPs on PCa. RESULTS 21 eligible articles containing 71 subgroups were included in this meta‐analysis. Significant associations were found between 31 SNPs and PCa. They were rs445114, rs620861, rs983085, rs1016343, rs1447295, rs1859962, rs2660753, rs2710646, rs2735839, rs3760511, rs4242382, rs4430796, rs4962416, rs5945572, rs5945619, rs6470494, rs6501455, rs6983267, rs6983561, rs7000448, rs7214479, rs7501939, rs7920517, rs7931342, rs9364554, rs9623117, rs10090154, rs10486567, rs10896449, rs10993994, and rs16901979. The weighted odds ratios for above SNPs ranged between 0.64 and 1.88 (all P < 0.05). Subgroup analysis further indicated that the significant associations of some SNPs existed only in specific ancestry population ( P < 10 −5 ). CONCLUSIONS The current meta‐analysis demonstrated the moderate effects of above 31 SNPs on PCa and 14 independent PCa risk loci were identified. Prostate 71: 209–224, 2011. © 2010 Wiley‐Liss, Inc.