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Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men
Author(s) -
Chen Marcelo,
Huang YuChuen,
Yang Stone,
Hsu JongMing,
Chang YenHwa,
Huang William JiShian,
Chen YiMing Arthur
Publication year - 2009
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.21084
Subject(s) - prostate cancer , medicine , prostate , oncology , genotyping , case control study , allele , disease , genotype , cancer , risk factor , gynecology , genetics , biology , gene
BACKGROUND Recently, independent genome‐wide scans have found multiple genetic variants at 8q24 to be associated with prostate cancer risk. This study was performed to determine whether two of the variants more strongly associated with prostate cancer risk in European and American populations, specifically rs16901979 and rs6983561, were also associated with prostate cancer risk in Taiwanese men. METHODS We conducted a case–control study comprising of 340 prostate patients and 336 healthy controls. Genotyping was performed for rs16901979 and rs6983561. Their association with disease stage, tumor grade, PSA level and disease aggressiveness was also determined. RESULTS The risk allele A of rs16901979 was associated with a 1.28‐fold increase in prostate cancer risk ( P = 0.046), and the risk allele C of rs6983561 was associated with a 1.40‐fold increase in prostate cancer risk ( P = 0.006). When compared with controls, the risk allele of rs6983561 was more frequent in patients with more aggressive disease. Analysis of the cumulative risk of rs1447295, a confirmed risk variant, and one of these markers showed that compared to men who do not have any of these risk variants, men who carry any combination of 1 or 2 risk genotypes have a gradually increased prostate cancer risk ( P for trend <0.001). CONCLUSION The variants rs16901979 and rs6983561 at 8q24 are associated with prostate cancer risk in Taiwanese men. Prostate 70: 502–507, 2010. © 2009 Wiley‐Liss, Inc.