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Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men
Author(s) -
Zheng Siqun Lilly,
Hsing Ann W.,
Sun Jielin,
Chu Lisa W.,
Yu Kai,
Li Ge,
Gao Zhengrong,
Kim SeongTae,
Isaacs William B.,
Shen MingChang,
Gao YuTang,
Hoover Robert N.,
Xu Jianfeng
Publication year - 2009
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.21076
Subject(s) - prostate cancer , prostate , medicine , oncology , prostate disease , cancer , gynecology
BACKGROUND Several genome‐wide association studies (GWAS) in populations of European descent have identified more than a dozen common genetic variants that are associated with prostate cancer risk. METHODS To determine whether these variants are also associated with prostate cancer risk in the Chinese population, we evaluated 17 prostate cancer susceptibility loci in a population‐based case–control study from Shanghai, including 288 prostate cancer cases and 155 population controls. RESULTS After adjustment for age, two of the 17 loci were significantly associated with prostate cancer risk, while the other 15 loci were suggestively associated with prostate cancer risk in this population. The strongest associations were found for chromosome 8q24 Region 2 (rs1016343: OR = 2.07, 95% CI: 1.35–3.20, P = 9.4 × 10 −4 ) and 8q24 Region 1 (rs10090154: OR = 2.07, 95% CI: 1.31–3.28, P = 0.002); additional single nucleotide polymorphisms (SNPs) assessed in these two 8q24 regions were also significant (OR Region2 = 1.92–2.05, P = 9.4 × 10 −4 to 0.003, and OR Region1 = 1.77–1.81, P = 0.01 for all SNPs). CONCLUSIONS Our study shows that multiple prostate cancer risk loci identified in European populations by GWAS are also associated with prostate cancer risk in Chinese men, a low‐risk population with mostly clinically relevant cancers. Larger studies in Chinese and Asian populations are needed to confirm these findings and the role of these risk loci in prostate cancer etiology in Asian men. Prostate 70: 425–432, 2010. © 2009 Wiley‐Liss, Inc.