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Caveolin‐1 overexpression is associated with aggressive prostate cancer recurrence
Author(s) -
Karam Jose A.,
Lotan Yair,
Roehrborn Claus G.,
Ashfaq Raheela,
Karakiewicz Pierre I.,
Shariat Shahrokh F.
Publication year - 2007
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20557
Subject(s) - medicine , prostate cancer , biochemical recurrence , prostatectomy , prostate , univariate analysis , cancer , oncology , pca3 , caveolin 1 , tissue microarray , urology , pathology , multivariate analysis
Abstract Background Caveolin‐1 protein suppresses apoptotic cell death in prostate cancer. The objectives of this study were to investigate the association of Caveolin‐1 expression with established features of prostate cancer as well as overall and aggressive disease recurrence in patients treated with radical prostatectomy (RP). Methods Caveolin‐1 immunostaining was performed on a tissue microarray containing prostatectomy specimen cores from 232 consecutive patients treated with RP for clinically localized prostatic adenocarcinoma. Caveolin‐1 over‐expression was defined as more than 50% of cells staining positively for Caveolin‐1. Patients were categorized as having features of aggressive disease recurrence if they had a positive metastatic work‐up, post‐recurrence PSA doubling time less than 10 months, and/or failure to respond to local salvage radiation therapy. Results Seventy patients (30.2%) exhibited over‐expression of Caveolin‐1. Caveolin‐1 over‐expression was associated with higher pathologic Gleason sum ( P = 0.038) and higher pre‐operative PSA level ( P = 0.024). Patients with Caveolin‐1 over‐expression were at increased risk of PSA recurrence after surgery ( P = 0.023) in univariate but not in standard post‐operative multivariate analysis. However, patients with Caveolin‐1 over‐expression were at increased risk of aggressive prostate cancer recurrence in both univariate and multivariate analysis ( P < 0.001 and P = 0.001, respectively). Conclusions Over‐expression of Caveolin‐1 was associated with established features of prostate cancer and aggressive PSA recurrence. Caveolin‐1 might help identify patients at high risk of developing aggressive prostate cancer recurrence, thus allowing selection of patients who might benefit from early systemic therapeutic intervention. Prostate 67: 614–622, 2007. © 2007 Wiley‐Liss, Inc.