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Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer
Author(s) -
Ramankulov Azizbek,
Lein Michael,
Kristiansen Glen,
Loening Stefan A.,
Jung Klaus
Publication year - 2006
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20540
Subject(s) - osteopontin , medicine , prostate cancer , n terminal telopeptide , bone metastasis , bone resorption , receiver operating characteristic , pathology , bone remodeling , cancer , oncology , osteocalcin , alkaline phosphatase , biology , biochemistry , enzyme
Background The study was undertaken to evaluate the diagnostic and prognostic value of plasma osteopontin (OPN) in comparison to bone markers as well as the relationships between the markers and clinico‐pathological factors in prostate cancer (PCa) patients. Methods OPN and the bone markers carboxyterminal‐telopeptide of type I collagen, bone‐specific alkaline phosphatase (bALP), and aminoterminal‐propeptide of type I procollagen (PINP) were measured in 90 PCa patients with and without bone metastases, 35 patients with benign prostatic hyperplasia, and 29 healthy men. Results OPN and bone markers were significantly elevated in patients with bone metastases compared to the other groups. Significant correlations were found between all four‐bone markers (r s = 0.43–0.79, all P < 0.01). OPN correlated with tumor grade (r s = 0.23, P < 0.05). In receiver‐operating characteristics (ROC) analyses, OPN and bone markers were effective in distinguishing PCa patients with and without bone metastases showing areas under the curve (AUC) between 0.80 and 0.88 (all P < 0.001). OPN had an AUC of 0.85 that increased in combination with bALP up to 0.93 providing at the point with the highest diagnostic accuracy both a sensitivity and specificity of about 90%. Kaplan–Meier analyses and Cox proportional hazards regression models showed decreased survival of patients with high OPN and bone marker levels, while only high OPN and PINP were independent negative prognostic factors for PCa‐related death. Conclusions OPN alone or in combination with bone markers is useful as diagnostic marker in the detection of bone metastases and as prognosticator in the survival prediction in PCa patients. Prostate 67:330–340, 2007. © 2006 Wiley‐Liss, Inc.