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Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer
Author(s) -
Pierce Brandon L.,
FriedrichsenKaryadi Danielle M.,
McIntosh Laura,
Deutsch Kerry,
Hood Lee,
Ostrander Elaine A.,
Austin Melissa A.,
Stanford Janet L.
Publication year - 2006
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20527
Subject(s) - prostate cancer , genetic linkage , cancer , linkage (software) , prostate , microsatellite , biology , genetics , genetic heterogeneity , medicine , oncology , phenotype , gene , allele
BACKGROUND Prostate cancer is a genetically heterogeneous disease. Using the occurrence of other cancers in hereditary prostate cancer (HPC) families is a promising strategy for developing genetically homogeneous data sets that can enhance the ability to identify susceptibility loci using linkage analysis. METHODS Twelve HPC families with the co‐occurrence of adenocarcinoma of the pancreas were selected from the Prostate Cancer Genetic Research Study (PROGRESS). Non‐parametric linkage analysis for a prostate/pancreas cancer susceptibility phenotype was performed using 441 genome‐wide microsatellite markers. RESULTS No statistically significant linkage signal was detected in this analysis. The strongest linkage signals, as measured by Kong and Cox LOD score (KC LOD), were observed on chromosomes 2q37.2‐q37.3 (KC LOD = 1.01; P = 0.02) and 16q23.2 (KC LOC = 1.05; P = 0.01). CONCLUSIONS Despite the lack of statistically significant findings, four chromosomal regions, three of which (2q, 16q, 17q) were previously noted as harboring potential susceptibility loci, showed suggestive linkage results in this scan. Prostate 67: 410–415, 2007. © 2006 Wiley‐Liss, Inc.