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Overexpression of cyclooxygenase‐2 in human prostate carcinoma and prostatic intraepithelial neoplasia‐association with increased expression of polo‐like kinase‐1
Author(s) -
Denkert Carsten,
Thoma Andrea,
Niesporek Silvia,
Weichert Wilko,
Koch Ines,
Noske Aurelia,
Schicktanz Hanka,
Burkhardt Mick,
Jung Klaus,
Dietel Manfred,
Kristiansen Glen
Publication year - 2007
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20467
Subject(s) - prostate , intraepithelial neoplasia , prostate cancer , medicine , carcinoma , cancer , pathology , cancer research , immunohistochemistry , oncology
BACKGROUND Cyclooxygenases (COX) as well as Polo‐like kinases (PLK) are involved in proliferation and cell cycle regulation and have been suggested for preventive and therapeutic approaches in prostate carcinoma. METHODS In this study, we studied expression and prognostic impact of COX‐2 in invasive prostate carcinoma, prostatic intraepithelial neoplasia (PIN), atrophic glands, and normal prostatic glands, and investigated the association between COX‐2 and PLK‐1. RESULTS We observed a positivity for COX‐2 in 72.1% of PIN and in 44.7% of prostate carcinomas with an overexpression of COX‐2 in prostate cancer and PIN compared to benign prostatic tissue ( P < 0.0005). Furthermore, we observed a strong correlation between expression of PLK‐1 and COX‐2 ( P < 0.0005). CONCLUSIONS To our knowledge, this is the first report of a correlation between COX‐2 and PLK‐1 in a malignant tumor. COX‐2 and PLK‐1 may be interesting targets for new molecular therapies in prostate cancer. Prostate 67: 361–369, 2007. © 2007 Wiley‐Liss, Inc.