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Presence of prostate cancer metastasis correlates with lower lymph node reactivity
Author(s) -
Philippe Olivier Gan,
Mona Alam Fahmy,
Louis Réal Bégin,
Audrey Djoukhadjian,
Abdelali FilaliMouhim,
Réjean Lapointe,
AnneMarie MesMasson,
Fred Saad
Publication year - 2006
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20466
Subject(s) - medicine , prostate cancer , metastasis , prostate , follicular hyperplasia , pathology , hyperplasia , lymph , lymph node , cancer , stromal cell , immunohistochemistry , cd68
BACKGROUND Several reports suggest that the dissemination of neoplastic cells and cancer progression are associated with the generation of an immunosuppressive environment. METHODS In this report, we investigated immunological effects of prostate cancer by comparing metastastic and non‐metastatic pelvic lymph nodes (LNs) from 25 patients with carcinomatous involvement of LNs to the non‐metastatic LNs from 26 control patients with no metastatic involvement by immunohistochemistry and histological analyses. RESULTS Our results showed a decreased abundance of CD20+ B lymphocytes ( P = 0.031), CD38+ activated lymphocytes ( P = 0.038), and CD68+ macrophages ( P < 0.001), and less evidence of follicular hyperplasia ( P = 0.014), sinus hyperplasia ( P < 0.001), and fibrosis ( P =0.028) in metastatic LNs comparatively to control LNs. Finally, we observed that metastatic LNs were significantly smaller than control LNs ( P = 0.005). CONCLUSIONS Our results suggest that the development of prostate cancer LN metastasis is accompanied with smaller LN size and decreased LN reactivity suggesting the development of an immununosuppressive microenvironment. © 2006 Wiley‐Liss, Inc.