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Clusterin is not essential for androgen‐regulated involution and regeneration of the normal mouse prostate
Author(s) -
Fink Dieter,
Fazli Ladan,
Aronow Bruce,
Gleave Martin E.,
Ong Christopher J.
Publication year - 2006
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20461
Subject(s) - clusterin , involution (esoterism) , prostate cancer , prostate , androgen , endocrinology , medicine , antiandrogen , biology , cancer research , hormone , cancer , apoptosis , consciousness , biochemistry , neuroscience
BACKGROUND Inhibition of clusterin expression has been shown to enhance the sensitivity of prostate cancer cells to chemo and hormone therapy. Clusterin antisense oligonucleotides (ASOs) are currently in phase II human clinical trials for treatment of hormone refractory prostate cancer. However, the role of clusterin in androgen‐regulated involution and regeneration of the normal prostate gland has not been established. METHODS Prostate involution and regeneration was examined in clusterin‐deficient mice undergoing up to three cycles of androgen withdrawal and restoration. RESULTS Surprisingly, clusterin deficiency did not affect the apoptotic index, and the temporal biochemical and morphological changes associated with involution and regeneration of the normal adult prostate following multiple rounds of androgen withdrawal and replacement. CONCLUSION Clusterin is not critical for normal prostate development or androgen‐regulated involution and regrowth of the mouse prostate gland, suggesting that clusterin may have distinct functions in malignant versus normal prostatic epithelial cells. Prostate 66: 1445–1454, 2006. © 2006 Wiley‐Liss, Inc.