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Molecular biological analysis of the heterogeneous prostate cancer group Gleason score 7
Author(s) -
Mian Christine,
Lodde Michele,
Comploj Evi,
Palermo Salvatore,
Lusuardi Lukas,
Marziani Fiovo,
Chiocchetti Andreas,
Spada Alessandra,
Mian Michael,
Pycha Armin
Publication year - 2006
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20418
Subject(s) - prostate cancer , prostate , medicine , cancer , oncology , prostate disease , gynecology
BACKGROUND On the basis of a multicolor‐FISH test we aimed at verifying whether there is any molecular biological background for the different behavior of Gleason Score 7 prostate cancer (PCa). PATIENTS AND METHODS Biopsies of 44 patients with histological verified PCa, 20 with Gleason score 3 + 4 (group A) and 24 with 4 + 3 (group B), were analyzed using FISH. RESULTS In group A, FISH detected a unique gain of 8q24 in 2 patients (10.0%) and a unique loss of 8p22 in 9 patients (45.0%). No concurrent loss and gain of both sites were found in this group. Of group B (4 + 3) a unique loss of 8p22 was observed in 14 patients (58.3%) and a concurrent loss of 8p22 and gain of 8q24 in 6 patients (25.0%). CONCLUSION Different molecular genetic patterns could explain the different biological behavior of the 2 groups. The analysis of chromosomal aberrations could therefore influence the clinical decision process in the future. Prostate 66: 966–970, 2006. © 2006 Wiley‐Liss, Inc.