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Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core
Author(s) -
Kawai Noriyasu,
Ito Akira,
Nakahara Yoko,
Honda Hiroyuki,
Kobayashi Takeshi,
Futakuchi Mitsuru,
Shirai Tomoyuki,
Tozawa Keiichi,
Kohri Kenjiro
Publication year - 2006
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20394
Subject(s) - hyperthermia , prostate cancer , prostate , in vivo , cationic liposome , medicine , cancer research , liposome , lncap , cancer , chemistry , biology , genetic enhancement , biochemistry , microbiology and biotechnology , gene
BACKGROUND Magnetite cationic liposomes (MCLs) can be used to induce hyperthermia because they generate heat in an alternating magnetic field (AMF). This study aimed at developing more practical method for MCL hyperthermia examining the effect of MCL‐induced hyperthermia on human prostate cancer in vivo .MATERIALS AND METHODS A newly developed AMF generator incorporating a solenoid with a ferrite core (FC) was used. Human prostate cancer cells (PC‐3 and LNCap) were injected subcutaneously into nude mice. MCLs were injected into tumor nodule and the mice were exposed into AMF three times at 24‐hr intervals (repeated hyperthermia; RH) until complete tumor regression was observed. RESULTS Irradiation with an AMF generated by newly developed device can adequately increase the temperature of tumor tissue. Frequent RH resulted in complete tumor regression in all nude mice. CONCLUSION RH using MCLs may be a promising new therapy for hormone‐refractory human prostate cancer in the future. Prostate © 2006 Wiley‐Liss, Inc.