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Allelotyping analysis at chromosome 13q of high‐grade prostatic intraepithelial neoplasia and clinically insignificant and significant prostate cancers
Author(s) -
Lu Wei,
Takahashi Hiroyuki,
Furusato Masakuni,
Maekawa Suguru,
Nakano Masataka,
Meng Chenxi,
Kikuchi Yasushi,
Sudo Akemi,
Hano Hiroshi
Publication year - 2005
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20363
Subject(s) - prostate cancer , loss of heterozygosity , high grade prostatic intraepithelial neoplasia , prostate , intraepithelial neoplasia , medicine , stage (stratigraphy) , oncology , pathology , cancer , allele , biology , genetics , paleontology , gene
BACKGROUND Loss of heterozygosity (LOH) at 13q is one of the most common chromosomal alterations in high‐stage prostate cancer, yet little is known about genetic changes in earlier‐stage prostate cancer. METHODS We used five microsatellite markers at 13q14, 21, and 33 to compare LOH frequencies in 51 lesions of high‐grade prostatic intraepithelial neoplasia (HGPIN), 21 cases of incidental prostate cancers (IPCs), 31 cases of latent prostate cancers (LPCs), and 102 cases of clinical prostate cancers (CPCs). RESULTS The frequency of LOH at 13q with at least 1 marker was 0%, 38%, 56%, and 49% in HGPIN, IPCs, LPCs, and CPCs, respectively. No statistically significant difference was found between the types of prostate cancer. Allelic loss at 13q14 was significantly more frequent in pT4 tumors than in earlier‐stage tumors ( P = 0.011). CONCLUSIONS Allelic loss at 13q is not only an important event in the metastasis of prostate cancer, but also associated with the initiation of the tumor. © 2005 Wiley‐Liss, Inc.