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Genomic search for prostate cancer predisposition loci in Utah pedigrees
Author(s) -
Camp Nicola J.,
Farnham James M.,
Can Albright Lisa A.
Publication year - 2005
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20287
Subject(s) - pedigree chart , linkage (software) , genetic linkage , genome scan , genetics , prostate cancer , biology , lod score , genome , microsatellite , computational biology , gene , gene mapping , cancer , allele , chromosome
BACKGROUND We report a genome linkage scan in extended Utah pedigrees, utilizing a pedigree‐splitting approach to reduce intra‐familial heterogeneity. METHODS Fifty‐nine pedigrees with at least four Prostate cancer (PrCa) cases and no more than two meioses separating PrCa cases were analyzed using the CIDR genomic search STRP marker set. Parametric linkage analyses using dominant and recessive models were performed on four datasets resulting from a pedigree splitting algorithm. In addition, age at diagnosis subset analyses were performed. RESULTS Four regions of interest (LODs > 1.9) were identified on chromosomes 1p, 3q, 5q, and 22q. The linkage peaks on 1p, 3q, and 22q have been previously implicated for PrCa, though not significantly. The 1p region was supported by a single large Utah pedigree with a multipoint LOD score of 3.1. An additional 10 regions gave LOD scores > 1.22 (nominal linkage evidence), including moderate evidence supporting the HPC20 region with a recessive model. CONCLUSIONS Our genome‐wide search in the informative, extended Utah pedigrees continues to illustrate an ability to identify and replicate linkage peaks, and supports four regions of interest for PrCa predisposition genes. © 2005 Wiley‐Liss, Inc.