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Sequence variation within the 5′ regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk
Author(s) -
Kidd La Creis R.,
Paltoo Di.,
Wang Songping,
Chen Weidong,
Akereyeni Folasade,
Isaacs William,
Ahaghotu Chiledum,
Kittles Rick
Publication year - 2005
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20204
Subject(s) - prostate cancer , gene , prostate , biology , sequence (biology) , genetics , cancer , medicine , endocrinology
Background The vitamin D receptor (VDR) and binding protein (DBP) mediate the cellular transport, activity, and anti‐tumor action of 1,25‐dihydroxyvitamin D3 [1,25‐(OH) 2 D3]. The purpose of this investigation is to determine whether novel single nucleotide polymorphisms (SNPs) within the transcriptional regulatory regions of the VDR and DBP are associated with prostate cancer risk. Methods Novel SNPs were identified in the VDR and DBP transcription regulatory gene regions and genotyped in a case‐control study using male subjects with (n = 258) or without (n = 434) prostate cancer. Results African‐American men who possessed at least one variant VDR‐5132 C allele had a increased risk of prostate cancer (OR = 1.83; 95% CI: 1.02, 3.31). Further study revealed that the VDR‐5132 T/C SNP eliminates a GATA‐1 transcription factor‐binding site. Conclusion The VDR‐5132 T/C SNP, resulting in potential elimination of the GATA‐1 transcription factor‐binding site, may increase prostate cancer susceptibility in African‐Americans. Confirmation of these findings is needed in larger observational studies. © 2005 Wiley‐Liss, Inc.