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Topographic distribution of lymphatic vessels in the normal human prostate
Author(s) -
Soh Shigehiro,
Ishii Toshiharu,
Sato Erina,
Akishima Yuri,
Ito Kinji,
Baba Shiro
Publication year - 2005
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20199
Subject(s) - prostate , lymphatic system , medicine , distribution (mathematics) , pathology , prostatic disease , anatomy , cancer , mathematical analysis , mathematics
BACKGROUND The lymphatic endothelial hyaluronan receptor (LYVE‐1) is a specific cell surface protein in lymphatic endothelium. The antiserum against human LYVE‐1 was developed and was confirmed a powerful marker of lymphatic endothelium in human organs. With this novel marker we investigated the small network of intraprostate lymphatic vessels. METHODS To identify intraprostatic lymphatic vessels, we performed an immunohistochemical staining method using LYVE‐1 pAb and von Willebrand Factor (vWF), and assessed the difference in distribution of small lymphatic vessels between the components in the prostate. RESULTS The density of lymphatic vessel was significantly high around ejaculatory ducts and in the fibromascular area between the globular area of peripheral zone and transitional zone. Predominat lymphatic vessels distributed in the fibromascular area in the anterior and posterior prostate of extrastromal area. CONCLUSIONS Recognition of the distinctive features of the intraprostate lymphatic network, can help the investigation of lymphatic involvement in cancer of the prostate. © 2004 Wiley‐Liss, Inc.