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Co‐factors p300 and CBP catch egr1 in their network
Author(s) -
Adamson Eileen D.,
Yu Jianxiu,
Mustelin Tomas
Publication year - 2005
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20186
Subject(s) - egr1 , transcription factor , transcription (linguistics) , prostate cancer , microbiology and biotechnology , cancer research , biology , cell growth , chemistry , cancer , genetics , gene , linguistics , philosophy
Abstract p300 and CBP are large (300 kDa) nuclear scaffold proteins that act as co‐activators of transcription in most cell types and are over‐expressed in prostate cancer. Recently, the Egr1 transcription factor was shown to up‐ or down‐regulate p300 and CBP transcription based on the nature of its post‐translational modification. Notably, interactions of the three proteins provide fine tuning for Egr1‐induced growth or cell death responses. © 2005 Wiley‐Liss, Inc.