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A phase II trial of imatinib mesylate in patients with prostate specific antigen progression after local therapy for prostate cancer
Author(s) -
Rao Kamakshi,
Goodin Susan,
Levitt Michael J.,
Dave Nisha,
Shih Weichung J.,
Lin Yong,
Capanna Terry,
DoyleLindrud Susan,
Juvidian Parisa,
DiPaola Robert S.
Publication year - 2004
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20130
Subject(s) - medicine , prostate , prostate cancer , imatinib mesylate , prostate specific antigen , prostate disease , oncology , cancer , imatinib , urology , myeloid leukemia
Abstract PURPOSE To test the hypothesis that progression of androgen sensitive prostate cancer is dependent on growth factors, such as platelet derived growth factor (PDGF), and inhibition of PDGF receptor (PDGF‐R) with imatinib will induce anti‐tumor activity. PATIENTS AND METHODS This phase II study evaluated imatinib in patients with androgen sensitive prostate cancer and prostate specific antigen (PSA) progression after local therapy. Patients received 400 mg of imatinib orally twice a day for 24 weeks (six cycles). Patients were monitored every 4 weeks for an effect on PSA and toxicity. Immunohistochemistry (IHC) for PDGF‐R was performed in available tumor specimens. RESULTS Twenty‐one patients were enrolled on this trial with a median age of 64 years. A total of 72 cycles of therapy were administered. Sixteen patients were evaluable for a response. Nine of the 16 patients demonstrated a stable PSA. Seven patients demonstrated PSA progression. Grade 3 and 4 toxicity included rash (4.1%), hematuria (1.4%), diarrhea (1.4%), and neutropenia (2.7%). Testosterone levels did not change during therapy. Four patients with available tumor demonstrated PDGF‐R alpha and beta by IHC. CONCLUSIONS This first study evaluated the efficacy and safety of imatinib in patients with early androgen sensitive prostate cancer following local therapy. As a single agent at this dosing, imatinib had limited biochemical activity. © 2004 Wiley‐Liss, Inc.