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Can color doppler predict the uniformity of HIFU‐induced prostate tissue destruction?
Author(s) -
Rouvière Olivier,
Curiel Laura,
Chapelon JeanYves,
Bouvier Raymonde,
Ecochard René,
Gelet Albert,
Lyonnet Denis
Publication year - 2004
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.20076
Subject(s) - medicine , prostate , high intensity focused ultrasound , prostate cancer , radiation therapy , radiology , hormonal therapy , ultrasound , nuclear medicine , perfusion , urology , cancer
Abstract Background Tissue blood perfusion influences the results of some hyperthermia and thermotherapy procedures, but its role in the outcome of prostate cancer treatment by high‐intensity focused ultrasound (HIFU) has not been evaluated yet. We evaluated preoperative prostate color Doppler as a predictor of the efficacy of HIFU treatment. Methods Thirty‐five patients underwent pre‐ and post‐contrast color Doppler examination of the prostate before HIFU treatment. Specific software was used to calculate, on color Doppler images, the color pixel density (CPD), and the specific flow (SF, i.e., mean velocity × CPD) in different regions of interest. Post‐treatment sextant biopsies were obtained in 31 patients, 5.8 ± 2.8 months after HIFU treatment. Results No significant correlation was found between the uniformity of HIFU‐induced tissue destruction observed on control biopsies and the pre‐treatment CPD/SF values in any region of interest, either before or after contrast injection. On the other hand, history of radiation therapy was significantly associated with homogeneous tissue destruction and history of hormone therapy was significantly associated with incomplete tissue destruction. Conclusions Color Doppler cannot predict the uniformity of HIFU‐induced tissue destruction. History of radiation therapy was found to be a factor of favorable prognosis and history of hormone therapy was found to be a factor of poor prognosis in our population. © 2004 Wiley‐Liss, Inc.