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Genome‐wide scan for linkage in finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25‐26
Author(s) -
Schleutker Johanna,
BaffoeBonnie Agnes B.,
Gillanders Elizabeth,
Kainu Tommi,
Jones MaryPat,
FreasLutz Diana,
Markey Carol,
Gildea Derek,
Riedesel Erica,
Albertus Julie,
Gibbs Kenneth D.,
Matikainen Mika,
Koivisto Pasi A.,
Tammela Teuvo,
BaileyWilson Joan E.,
Trent Jeffrey M.,
Kallioniemi OlliP.
Publication year - 2003
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.10302
Subject(s) - genetics , population , genetic linkage , multiplex , linkage (software) , prostate cancer , cancer , microsatellite , biology , medicine , oncology , allele , gene , environmental health
Abstract BACKGROUND In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome‐wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. METHODS Altogether 87 DNA samples were genotyped from 13 families. Logarithm‐of‐odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown. RESULTS The highest LOD scores in the affected‐only analyses were found at 11q14, where the two‐point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non‐parametric‐linkage (NPL) score of 2.67 ( P = 0.008). A second positive site was at 3p25‐26, with a two‐point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 ( P = 0.02). CONCLUSIONS The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study. Prostate 57: 280–289, 2003. © 2003 Wiley‐Liss, Inc.