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Where are the prostate cancer genes?—A summary of eight genome wide searches
Author(s) -
Easton Douglas F.,
Schaid Daniel J.,
Whittemore Alice S.,
Isaacs William J.
Publication year - 2003
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.10300
Subject(s) - prostate cancer , linkage (software) , genetic linkage , genome , prostate , cancer , gene , genetics , biology , oncology , medicine
BACKGROUND There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified. METHODS We reviewed the results of eight genome‐wide linkage searches based on 1,293 families with multiple cases of prostate cancer. RESULTS Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group. CONCLUSIONS These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence. Prostate 57: 261–269, 2003. © 2003 Wiley‐Liss, Inc.