Premium
Expression of peroxisome proliferator‐activated receptor (PPAR) in human prostate cancer
Author(s) -
Segawa Yoshihiro,
Yoshimura Rikio,
Hase Taro,
Nakatani Tatsuya,
Wada Seiji,
Kawahito Yutaka,
Kishimoto Taketoshi,
Sano Hajime
Publication year - 2002
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/pros.10058
Subject(s) - peroxisome proliferator activated receptor , prostate cancer , prostate , immunohistochemistry , cancer , receptor , endocrinology , medicine , hyperplasia , cancer research , apoptosis , pathology , biology , biochemistry
BACKGROUND Recent studies have demonstrated that peroxisome proliferator activator‐receptors (PPAR)‐γ is expressed in some cancer cells such as breast, lung, and gastric cancer, and its ligand induces growth arrest of these cancer cells through apoptosis. However, the expression and localization of PPARs in prostate have not been examined. In this study, PPARs expression was investigated in human prostate cancer (PC), prostatic intraepithelial neoplasia (PIN), benign prostatic hyperplasia (BPH), and normal prostate (NP) tissues. METHODS Tumor specimens were obtained from 156 patients with PC, 15 with PIN, 20 with BPH, and 12 patients with NP tissues. The expressions were investigated by RT‐PCR and immunohistochemical methods. RESULTS Immunoreactive PPAR‐α and ‐β were significantly apparent in PC tissues. Marked expressions of PPAR‐α and ‐β were also detected in PIN, BPH, and NP groups. However, very weak or no expression of immunoreactive PPAR‐γ was found in BPH and NP cases. In contrast, we found significant expression of immunoreactive PPAR‐γ in cancer cells in PC group and in PIN group. CONCLUSIONS Our results demonstrated that PPAR‐γ is induced in PC, and suggest that PPAR‐γ ligands may mediate its own potent antiproliferative effect against PC cells through differentiation. Prostate 51: 108–116, 2002. © 2002 Wiley‐Liss, Inc.