Open AccessCombined treatment modality in pediatric infratentorial midline high‐grade glioma can lead to long‐term survival: A case study and review of literature
Author(s) -
Das Majumdar Saroj,
Dhar Sovan Sarang,
Lalsangzuala Chinzah,
Sahu Rabi,
Purkait Suvendu,
Parida Dillip
Publication year - 2021
Publication title -
precision radiation oncology
Language(s) - English
Resource type - Journals
ISSN - 2398-7324
DOI - 10.1002/pro6.1127
Subject(s) - medicine , radiation therapy , chemotherapy , glioma , treatment modality , surgical resection , external beam radiotherapy , central nervous system , resection , disease , surgery , pediatrics , oncology , brachytherapy , cancer research
Central nervous system high‐grade glioma (HGG) occurring in an infratentorial midline location is not commonly found in the pediatric population. Though pediatric HGGs appear similar to their adult counterparts histopathologically, they differ in molecular, genetic, and clinical characteristics. Evidence for the management of HGG is sparse in the literature. Surgery in the form of maximum safe resection is the backbone of management and has been variably supplemented with external beam radiotherapy and cytotoxic chemotherapy. The outcome, though largely dismal, has some positive surprises too. As shown in the presented case, the combined modality of management in a 5‐year‐old female child has resulted in a disease‐free survival of 3.5 years.