Premium
Class‐directed structure determination: Foundation for a protein structure initiative
Author(s) -
Terwilliger Thomas C.,
Waldo Geoffrey,
Peat Thomas S.,
Newman Janet M.,
And Kelvin Chu,
Berendzen Joel
Publication year - 1998
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560070901
Subject(s) - foundation (evidence) , protein structure , protein structure prediction , class (philosophy) , computational biology , physics , computer science , biology , political science , artificial intelligence , nuclear magnetic resonance , law
The recent sequencing of many complete genomes, combined with the development of methods that allow rapid structure determination for many proteins, has changed the way in which protein structure determinations can be approached. One‐by‐one determinations of individual protein structures will soon be augmented by class‐directed structure analyses in which a group of proteins is targeted and structures of representative members are determined and used to represent the entire group. Such a shift in approach would be the foundation for a broad protein structure initiative targeting classes of proteins important for biotechnology and for a fundamental understanding of protein function.