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Three‐dimensional structures and contexts associated with recurrent amino acid sequence patterns
Author(s) -
Han Karen E,
Bystroff Christopher,
Baker David
Publication year - 1997
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560060723
Subject(s) - sequence (biology) , cluster (spacecraft) , computational biology , peptide sequence , evolutionary biology , sequence logo , biology , loop modeling , sequence alignment , protein structure , sequence analysis , genetics , computer science , gene , biochemistry , programming language
We have used cluster analysis to identify recurring sequence patterns that transcend protein family boundaries. A subset of these patterns occur predominantly in a single type of local structure in proteins. Here we characterize the three‐dimensional structures and contexts in which these sequence patterns occur, with particular attention to the interactions responsible for their structural selectivity.