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Architecture of helix bundle membrane proteins: An analysis of cytochrome c oxidase from bovine mitochondria
Author(s) -
Wallin Erik,
Tsukihara Tomitake,
Yoshikawa Shinya,
Heijne Gunnar Von,
Elofsson Arne
Publication year - 1997
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560060407
Subject(s) - cytochrome c oxidase , bacteriorhodopsin , cytochrome c , chemistry , mitochondrion , biochemistry , membrane protein , membrane , biophysics , biology
We have analyzed the structure of mitochondrial cytochrome c oxidase in terms of general characteristics thought to be important for describing the architecture of helix bundle membrane proteins. Many aspects of the structure are similar to what has previously been found for the photosynthetic reaction center and bacteriorhodopsin. Our results lead to a considerably more precise general picture of membrane protein architecture than has hitherto been possible to obtain.