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Saccharomyces cerevisiae mitochondria lack a bacterial‐type Sec machinery
Author(s) -
Glick Benjamin S.,
Heijne Gunnar Von
Publication year - 1996
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560051229
Subject(s) - saccharomyces cerevisiae , intermembrane space , mitochondrion , yeast , biology , protein targeting , inner membrane , genetics , microbiology and biotechnology , gene , membrane protein , bacterial outer membrane , escherichia coli , membrane
The bacterial Sec genes encode a generalized protein export machinery. Although the mitochondria present in eukaryotic cells are derived from bacterial ancestors, a comprehensive search of the complete genomic sequence for the eukaryotic yeast Saccharomyces cerevisiae did not reveal any close homologs of the bacterial Sec genes, strongly suggesting that yeast mitochondria lack a generalized bacterial‐type export system. This finding has implications for the sorting of imported mitochondrial proteins to the intermembrane space compartment, and also for the insertion of mitochondrially encoded proteins into the inner membrane.